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KMID : 0359319670070020051
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Korean Journal of Veterinary Research
1967 Volume.7 No. 2 p.51 ~ p.55
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Mammary and renal excretion of sulphamethomidine in cows
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이장락/Lee, Jang Nag
Kjarsgaard, Per
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Abstract
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The mammary excretion of suphamethomidine after intravenous and/or oral administration was investigated in cows.
The results show that sulphamethomidine is bound to plasma proteins to a great extent (80∼90%). At a dosage of 60 ㎎./㎏. maximal concenration in plasma of this sulphonamide was reached 7-10 hours after oral dosing. The sulphonamide concentration in plasma slowly declined after both oral and intravenous administration (fig. 1, 2, and 3)
The concentration of sulphonamide in milk was very low and the excretion was completed in 7 days after a single oral dose and 5 days after intravenous injection while in the case of blood plasma it was 11 and 7 days, respectively.
In addition, the renal excretion of sulphamethamidine was investigated while under continuous intraveuous intravenous infusion. The excretion ratios varies according to self depression (table. 1). Blockade of the tubular secretion with diodone lowered tire excretion of sulphamethomidine. It is concluded that the renal excretion of sulphamethomidine in cows occurs by filtration by slight tubular secretion and also by a high rate of back diffusion.
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